Signal · Product Feed

DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7

DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7

Name: DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7
Brand: trulybuild.in
SKU: 97837134297
Price: 69.00 USD
Availability: InStock
Rating: 4.4536 (30 reviews)

SKU: 97837134297

4.5

USD69.00 USD117.00

Pay in 4 interest-free payments of $17.25 Learn more

Shipping Estimate
USA

USA

CAN

Ships within 48 hours · Estimated delivery Aug 13 - Aug 18

Live Spec

DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7DASA 58 (ML203), CAS No. 1203494 49 8, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA 58 inhibits LPS induced Hif 1 and IL 1, as well as the expression of a range of other Hif 1 dependent

Store: trulybuild.in · Domain: trulybuild.in

Description

InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7

It is highly selective over related enzymes such as MAO-A/B

CAS Number: 847925-91-1

2013 Jul 18

It may represent a good lead compound for a subset of Parkinson's disease

Exchange/Return Notes