CYC-116 0-IN-1 27(1):47-56

27(1):47-56

is a serine protease inhibitor and an anticoagulant

612847-09-3

Hesperetin suppresses NF-κB activation and reduces cholesterol biosynthesis

CAS Number: 54739-18-3

CYC-116 0-IN-1 27(1):47-56CYC116 is an orally bioavailable small molecule multi kinase inhibitor with antineoplastic activity. Aurora kinase VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine threonine protein kinases that are only expressed in actively dividing cells and are critical in