Topotecan denosine 1585:159-66

1585:159-66

4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49

(E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide 4-methylbenzenesulfonate

IC87114 (5 µM) also inhibits polarized morphology and spreading of neutrophils

Formula: C13H13BrN2OS

Topotecan denosine 1585:159-66Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I DNA covalent complexes, inhibiting religation of topoisomerase I mediated single strand DNA breaks and producing potentially lethal double strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline based alkaloid