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ARRY-520 (R) 30002 Absorption is relatively rapid in

SKU: 95554640249

4.2
USD100.00 USD139.00

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ARRY-520 (R) 30002 Absorption is relatively rapid inARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product

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Description

Absorption is relatively rapid in dogs but slower in mice (10 mg/kg)

Smiles: CC(C)OC1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C21

Devereux S

Formulation: 5

4% Tween-80

ARRY-520 (R) 30002 Absorption is relatively rapid inARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product

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