Gamabufotalin Catalog No.:M8396-2 It binds to both the

It binds to both the α4β2 and α7 subtypes

6-tetramethylphenyl)amino)-N-methylacetamido)piperidin-1-yl)methyl)benzamide

33)/t16-/m0/s1

CADTH Canadian Drug Expert Committee Recommendation: Obeticholic Acid (Ocaliva — Intercept Pharmaceuticals Canada): Indication: Primary biliary cholangitis [Internet]

CAS Number: 190786-44-8

Gamabufotalin Catalog No.:M8396-2 It binds to both theGamabufotalin (Gamabufagin), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. IC50 value: Target: in vitro: Gamabufotalin (CS 6) strongly suppressed COX 2 expression by inhibiting the phosphorylation of IKK via targeting the ATP binding site, thereby abrogating NF B binding and p300 recruitment to COX 2 promoter. In addition, CS 6 induced apoptosis by activating the