NVP-BHG712 Size:2mg solid suppresses tumor growth

suppresses tumor growth

5-1 µM concentration in beta cell proliferation assays

Di Carlo M

[1] GSK461364 shows a dose-dependent mitotic arrest in mouse xenografts

InChi: InChI=1S/C68H90N6O17S/c1-11-51(48-35-57(84-8)61(86-10)58(36-48)85-9)65(79)73-27-13-12-17-52(73)67(81)91-54(24-20-44-21-25-55(82-6)56(33-44)83-7)47-15-14-16-50(34-47)90-41-59(76)69-26-28-87-29-30-88-31-32-89-40-60(77)72-63(68(3

NVP-BHG712 Size:2mg solid suppresses tumor growthNVP BHG712, also known as BHG 712, is a EphB4 kinase inhibitor and BCR ABL inhibitor. NVP BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. BHG 712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral