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CI994 (Tacedinaline) - HDAC Inhibitor. CAS# 112522-64-2 0420 and rabbit liver (IC50=0

CI994 (Tacedinaline) - HDAC Inhibitor. CAS# 112522-64-2 0420 and rabbit liver (IC50=0

Name: CI994 (Tacedinaline) - HDAC Inhibitor. CAS# 112522-64-2 0420 and rabbit liver (IC50=0
Brand: trulybuild.in
SKU: 78733034522
Price: 30.00 USD
Availability: InStock
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SKU: 78733034522

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CI994 (Tacedinaline) - HDAC Inhibitor. CAS# 112522-64-2 0420 and rabbit liver (IC50=0CI994 (Tacedinaline), CAS No. 112522 64 2, is a potent, selective and orally active histone deacetylase (HDAC) inhibitor. It inhibits HDAC1 (IC50 ~0. 57 M), HDAC2 (IC50 ~0. 90 M) and HDAC3 (IC50 ~1. 2 M). It does not inhibit HDAC6 and HDAC8 (IC50 >100 M). CI994 mediates G1 cell cycle arrest, inhibits proliferation, and induces apoptosis in tumor cell lines. It has also demonstrated antitumor activity in several tumor models, including the chemo

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Description

and rabbit liver (IC50=0

1009820-21-6

the human breast cancer MDA-MB-453 cells and the normal mouse fibroblasts (NIH 3T3)

) demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft models

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