LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 Angew Chem Int Ed Engl

Angew Chem Int Ed Engl

I-BRD9 was used at 10 µM final concentration in vitro and in cellular assays

It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference

It was also used in an assay where primary bovine articular chondrocytes and cartilage explants were grown in the presence of TNF-a and oncostatin M to mimic cytokine-induced damage during OA pathogenesis

A very useful small molecule collection to improve CRISPR editing efficacy

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 Angew Chem Int Ed EnglLY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is