ADX47273 - CAS# 851881-60-2 0127 IOX4 was used at 10-50

IOX4 was used at 10-50 µM final concentration in vitro and in cellular assays

with elimination half-lives of 6

The deleterious synergistic effect between ER-stress and ISRIB may be generally advantageous to kill cancer cells

de Alwis DP

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

ADX47273 - CAS# 851881-60-2 0127 IOX4 was used at 10-50ADX 47273, CAS No. 851881 60 2, is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC50 = 0. 17 m, with no effect on other mGluR subtypes. In vivo, ADX47273 increased extracellular signal regulated kinase and cAMP responsive element binding protein phosphorylation in hippocampus and prefrontal cortex, both of which are critical for glutamate mediated signal transduction mechanisms. The mGluR (metabotropic glutamate