Fenretinide - CAS# 65646-68-6 127 A decrease in CMA activity

A decrease in CMA activity occurs in aging and in age-related disorders (such as neurodegenerative diseases and diabetes)

Zajac-Kaye M

(2008) J Med Chem

PubMed PMID: 21940661

Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure

Fenretinide - CAS# 65646-68-6 127 A decrease in CMA activityFenretinide, CAS No. 65646 68 6, is an orally active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis associated growth factors and their receptors and exhibits retinoid