JNJ-40411813 mifugin InChi: InChI=1S/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10
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JNJ-40411813 mifugin InChi: InChI=1S/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10JNJ 40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ 40411813 acts as a PAM at the cloned mGlu2 receptor: EC50 = 147 42 nmol L in a [(35)S]GTPS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50 = 64 29 nmol L in a Ca(2+) mobilization assay with hmGlu2 G 16 cotransfected HEK293 cells. JNJ 40411813 displaced [(3)H]JNJ 40068782 and [(3)H]JNJ 46281222 (mGlu2 receptor PAMs),
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