(+)-JQ-1 asanutlin Formula: C10H14N2O6

Formula: C10H14N2O6

Chemical Name: 1-carbamimidamido-N

Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent

54(41):12020-4

good ancillary pharmacology

(+)-JQ-1 asanutlin Formula: C10H14N2O6(+) JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of