CX-4945 - CK2 (Casein Kinase 2) Inhibitor. CAS# 1009820-21-6 Catalog No.:M60267-10S 12(7):531-8

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CX-4945 - CK2 (Casein Kinase 2) Inhibitor. CAS# 1009820-21-6 Catalog No.:M60267-10S 12(7):531-8CX 4945 (Silmitasertib), CAS No. 1009820 21 6, is a potent, selective and bioavailable CK2 (Casein Kinase 2) Inhibitor with IC50 of 1 nM. It only inhibits 7 of the 238 kinases by more than 90% at concentration of 0. 5 M, which is 500 fold selectivity over CK2. Although in cell free systems CX 4945 inhibits FLT3, PIM1, and CDK1 with IC50 of 35 nM, 46 nM, and 56 nM, respectively, but it is inactive against FLT3, PIM1, and CDK1 in cell based functional

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