Corynoxine B upitant metabolite Monohydroxy Netupitant Formula: C31H38N6O2

Formula: C31H38N6O2

MK-422 D5 Sodium Salt

with an extrapolated geometric mean IC50 of approximately 20 mM resulting in a predicted selectivity index of 166

suggesting a critical role of ATM kinase in regulating AKT phosphorylation via unknown phosphatase

PubMed PMID: 25130662

Corynoxine B upitant metabolite Monohydroxy Netupitant Formula: C31H38N6O2Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin 1 dependent autophagy inducer. IC50 value: Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA HMGB1 interaction . in vivo: Corynoxine B exhibited prolongation