AZD4547 ratriptan It increases H3K4 methylation selectively

It increases H3K4 methylation selectively at genomic regions bound by LSD1

TCID can diminish glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons

PubMed Central PMCID: PMC4275380

Chemical Name: N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1

N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[[[5-(2-thienyl)-3-pyridinyl]carbonyl]amino]-

AZD4547 ratriptan It increases H3K4 methylation selectivelyAZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation,