TIC10 Catalog No.:M8469-10 Food Addit Contam Part A

Food Addit Contam Part A Chem Anal Control Expo Risk Assess

is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0

CAS Number: 819812-04-9

[2H]C([2H])([2H])N1C2=CC=CC=C2C2C(=O)N(CC3N=CNC=3C)CCC1=2

RU-SKI 43 was used at 10-20 µM final concentration in vitro and in cellular assays

TIC10 Catalog No.:M8469-10 Food Addit Contam Part AONC 201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53 independent manner and crosses the blood brain barrier. TIC10 induces a sustained up regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal regulated kinase (ERK), leading to the translocation