RO4929097 - γ-Secretase Inhibitor. CAS#847925-91-1 326 inhibits prosurvival and angiogenic signaling

inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy

951441-04-6

Solubility: Soluble in DMSO

The average tumor weight of S3I-201-treated rats is 78±8 mg

Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1

RO4929097 - γ-Secretase Inhibitor. CAS#847925-91-1 326 inhibits prosurvival and angiogenic signalingRO4929097, CAS No. 847925 91 1, is a highly potent and selective secretase inhibitor with an IC50 ~4 nM. It can cause a dramatic reduction of the intracellular Notch level and lead to significantly decreased expression of the Notch transcriptional target genes, such as Hes1. It exhibits potent inhibitory activity of Notch signaling in tumor cells. Currently RO4929097 is in multiple phase I II clinical trials to treat cancer. Product information CAS