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Refametinib (R) loxacin Hydrochloride 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1
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Refametinib (R) loxacin Hydrochloride 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1Refametinib R enantiomer is a potent, selective and allosteric inhibitor of MEK1 2 in enzyme inhibition assays. Refametinib R has been reported to inhibit MEK activity and inhibit anchorage dependent growth. Moreover, it has shown a potent tumor growth inhibition (TGI) in the human A375 and colon carcinoma Colo205 tumor xenograft models. Product information CAS Number: 923032 38 6 Molecular Weight: 572. 34 Formula: C19H20F3IN2O5S Synonym: BAY 869766 R
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