CHR-6494 - CAS# 1333377-65-3 Catalog No.:M10283-2 6-dichlorophenyl)-4

6-dichlorophenyl)-4

Gamabufagin

The deleterious synergistic effect between ER-stress and ISRIB may be generally advantageous to kill cancer cells

providing biochemical evidence of NMDA receptor antagonism in vivo

The high dose for both MLN2238 and Bortezomib shows similar antitumor activity in this model (T/C=0

CHR-6494 - CAS# 1333377-65-3 Catalog No.:M10283-2 6-dichlorophenyl)-4CHR 6494 is a potent and selective histone kinase Haspin inhibitor. CHR 6494 reduces H3T3ph levels in a dose dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. CHR 6494 shows antitumor potential in xenografted nude mice without any observed toxicity. Thus, CHR 6494 is a first in class Haspin inhibitor with a wide spectrum of anticancer effects that merits