Lonafarnib - CAS# 193275-84-2 702 is potentially for the treatment

is potentially for the treatment of malaria

Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity

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Metformin (500 μM) or AICAR strongly suppresses SREBP-1 mRNA expression in rat hepatocytes

CAS Number: 511-28-4

Lonafarnib - CAS# 193275-84-2 702 is potentially for the treatmentLonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras