DT2216 Size:2mg solid Afuresertib-induced p21 expression promotes G1

Afuresertib-induced p21 expression promotes G1 phase arrest by inducing FOXO activity

PubMed PMID: 24500879

MK-1775 was orally dosed to mice at 20 mg/Kg once per day

21(4 Pt 1):723-7

Dp44mT shows the greatest antitumor efficacy with an IC50 that ranged from 0

DT2216 Size:2mg solid Afuresertib-induced p21 expression promotes G1DT2216 is a potent and selective degrader of BCL XL based on PROTAC technology. DT2216 inhibits various BCL XL dependent leukemia and cancer cells but considerably less toxic to platelets. Product information CAS Number: 2365172 42 3 Molecular Weight: 1542. 36 Formula: C77H96ClF3N10O10S4 Chemical Name: (2S,4R) 1 ((S) 2 (7 (4 ((R) 3 ((4 (N (4 (4 ((4' chloro 4,4 dimethyl 3,4,5,6 tetrahydro [1,1' biphenyl] 2 yl)methyl)piperazin 1 yl)benzoyl)sulfamoyl) 2