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VCP 171 Size:2mg solid Nature Med

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VCP 171 Size:2mg solid Nature MedAdenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5. 65, binding cooperativity with NECA 0. 68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve injury model of neuropathic pain. Product information CAS Number: 1018830 99 3 Molecular

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Nature Med

Degradation Inducing Moiety A

NIBR3049 shows moderate activity in this cellular assay (IC50=689 nM

either Ser/Thr- or Tyr-specific

61(9):797-805

VCP 171 Size:2mg solid Nature MedAdenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5. 65, binding cooperativity with NECA 0. 68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve injury model of neuropathic pain. Product information CAS Number: 1018830 99 3 Molecular

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