sirtinol - CAS# 410536-97-9 217 Smiles: CN1CCN(CC2=CC=C(C=C2C(F)(F)F)NC(=O)NC2C=CC(=CC=2)OC2=CC(NC(=O)C3CC3)=NC=N2)CC1

Smiles: CN1CCN(CC2=CC=C(C=C2C(F)(F)F)NC(=O)NC2C=CC(=CC=2)OC2=CC(NC(=O)C3CC3)=NC=N2)CC1

Go6983 was used at 1-5 µM final concentration in vitro and in cellular assays

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM

In vivo CUDC-101 promotes tumor regression in various cancer xenograft models such as non-small cell lung cancer (NSCLC)

sirtinol - CAS# 410536-97-9 217 Smiles: CN1CCN(CC2=CC=C(C=C2C(F)(F)F)NC(=O)NC2C=CC(=CC=2)OC2=CC(NC(=O)C3CC3)=NC=N2)CC1Sirtinol, CAS No. 410536 97 9, is a SIRT inhibitor. Sirtinol significantly increased the acetylation of p53, which has been reported to be a target of SIRT1 2. Sirtinol significantly increased the G1 phase of the cell cycle. Product information CAS Number: 410536 97 9 Molecular Weight: 394. 47 Formula: C26H22N2O2 Synonym: Sirtinol 2 [(2 Hydroxynaphthalen 1 ylmethylene)amino] N (1 phenethyl)benzamide 2 {[(2 hydroxy 1 naphthyl)methylene]amino} N (1