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VH 298 20046 Discovery of non-covalent inhibitors of
VH 298 20046 Discovery of non-covalent inhibitors of
VH 298 20046 Discovery of non-covalent inhibitors of
VH 298 20046 Discovery of non-covalent inhibitors of

VH 298 20046 Discovery of non-covalent inhibitors of

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VH 298 20046 Discovery of non-covalent inhibitors ofVH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85

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Description

Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro

4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13

145888-79-5

Indisulam (E7070)

InChi: InChI=1S/C15H22N2

VH 298 20046 Discovery of non-covalent inhibitors ofVH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85

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