[C@H]1C(=O)O[C@H](C)[C@H](NC(C)=O)C(=O)O[C@H](CC2C=CC=CC=2)C(=O)N(C)C(=C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N[C@@H]([C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C)C(=O)N1C](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10721_1621562358.gif?v=1621562360)
RJR-2403 (oxalate) Size:Solid 2 mg Smiles: CO[C@H](C)[C@H]1C(=O)O[C@H](C)[C@H](NC(C)=O)C(=O)O[C@H](CC2C=CC=CC=2)C(=O)N(C)C(=C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N[C@@H]([C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C)C(=O)N1C
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RJR-2403 (oxalate) Size:Solid 2 mg Smiles: CO[C@H](C)[C@H]1C(=O)O[C@H](C)[C@H](NC(C)=O)C(=O)O[C@H](CC2C=CC=CC=2)C(=O)N(C)C(=C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N[C@@H]([C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C)C(=O)N1CMetanicotine, also known as RJR 2403 and TC 2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the 42 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 + 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 + 155 nM and Emax = 91 + 8% for RJR 2403; EC50 = 591 + 120 nM and Emax = 100 + 25% for nicotine) . Chronic administration of RJR 2403 in combination with low
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