SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 Catalog No.:M60015-2S FLT3-D835Y

FLT3-D835Y

S3I-201 inhibits breast carcinoma MDA-MB-435

Bromosporine

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II

InChi: InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H

SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 Catalog No.:M60015-2S FLT3-D835YSB 431542, CAS No. 301836 41 9, is a potent and selective inhibitor of TGF type I receptors ALK5 (IC50 ~94 nM), ALK4 (IC50 ~140 nM) and ALK7. It has no activities on the other ALK family members such as ALK2, ALK3 and ALK6, nor on components of the ERK, JNK, and p38 MAP kinase pathways. It specifically blocks Smad2 signaling, modulating gene expression related to EMT. In several publications SB 431542 has been used to enhance iPSC reprogramming,