TM199 Rabbit Polyclonal Antibody, 20ul Culture Plate Inserts Cleaves preferentially Lys-6 and Lys-63-linked

Cleaves preferentially Lys-6 and Lys-63-linked ubiquitin chains

The encoded enzyme contains a hydrolase domain at the N-terminal portion

Multiple transcript variants encoding different isoforms have been characterized for this gene

This difference in size is largely due to an increase in the number of subdomains

Reduced levels of autophagy have been described in some malignant tumors

TM199 Rabbit Polyclonal Antibody, 20ul Culture Plate Inserts Cleaves preferentially Lys-6 and Lys-63-linkedThe protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER) Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) in some human cells. The encoded protein shares some homology with the yeast protein Vma12. Defects in this gene are a cause of congenital disorder of glycosylation type IIp.