Rat Insulin-like Growth Factors 1 Receptor, IGF-1R ELISA Kit, 96T DNA Fragments Channels containing GRIN1 and GRIN2A

Channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than Channels formed by GRIN1 and GRIN2B (PubMed: 28384476)

It is also involved in oogenesis and in neuronal differentiation

Mutations in this gene are associated with several congenital cardiovascular malformations

Also regulates the centrosome organization (PubMed: 18045989

The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system

Rat Insulin-like Growth Factors 1 Receptor, IGF-1R ELISA Kit, 96T DNA Fragments Channels containing GRIN1 and GRIN2AReceptor tyrosine kinase which mediates actions of Insulin like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates,