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CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer This gene may play a

SKU: 9363673635

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SEK162.00 SEK193.00

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CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer This gene may play aCortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F actin and Arp2 3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin

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Description

This gene may play a role in development of the liver

An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714)

a helical hinge region involved in oligomerization

The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting

and can bind the class III Arf ARF6 without immediate GAP activity

CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer This gene may play aCortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F actin and Arp2 3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin

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