Alpha-protein Kinase 1 Polyclonal Antibody, 50ul Cellular Function Assays MAP3K3/MEKK5

MAP3K3/MEKK5

The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription

Activating transcription factor 5 binds the cAMP response element (CRE)(consensus: 5'-GTGACGT[AC][AG]-3')

|tissue specificity:Ubiquitous

Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10)

Alpha-protein Kinase 1 Polyclonal Antibody, 50ul Cellular Function Assays MAP3K3/MEKK5ALPK1 encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene.