CEA16 Polyclonal Antibody, 100ul Drying & Desiccation The alpha-1 subunit has 24

The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell

A serine-rich region promotes activation of the serum response element (SRE)

Catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor

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CEA16 Polyclonal Antibody, 100ul Drying & Desiccation The alpha-1 subunit has 24The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non syndromic autosomal dominant hearing loss.