p27 Polyclonal Antibody, 100ul[BT-AP06756] Pathway and Network Analysis Nucleotide variation in this gene

Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia

and (in human) retinal degeneration

The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway

It is similar to some thermostable class II fumarases and functions as a homotetramer

Overexpression of BCL2L12 has been detected in a number of different cancers

p27 Polyclonal Antibody, 100ul[BT-AP06756] Pathway and Network Analysis Nucleotide variation in this geneCDKN1B encodes a cyclin dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A p21. The cyclin dependent kinase inhibitor 1B binds to and prevents the activation of cyclin E CDK2 or cyclin D CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the