Human Peripheral Plasma Membrane Protein Cask, CASK ELISA Kit , 96T Peptide Synthesis A bridging helix emanates from

A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition

possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane

Some of its substrates include transforming growth factor beta related proteins| proalbumin| and von Willebrand factor

The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth

This protein was reported to be specifically cleaved by CASP3-like caspases

Human Peripheral Plasma Membrane Protein Cask, CASK ELISA Kit , 96T Peptide Synthesis A bridging helix emanates fromMultidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion Channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with