Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter CHRNA1 encodes an alpha subunit

CHRNA1 encodes an alpha subunit that plays a role in acetlycholine binding/channel gating

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes

The protein localizes to cell membranes

A pseudogene COX17P has been found on chromosome 13

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Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter CHRNA1 encodes an alpha subunitMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.