EHMT2 Polyclonal Antibody, 50ul Cellular Function Assays Mutations in ATP7A are associated

Mutations in ATP7A are associated with Menkes disease

GAS8 includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer

Breast cancer metastasis-suppressor 1 encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC)

The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712)

Notch 2 is cleaved in the trans-Golgi network

EHMT2 Polyclonal Antibody, 50ul Cellular Function Assays Mutations in ATP7A are associatedThis gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants.