Tuberin Polyclonal Antibody, 50ul[BT-AP09285] Cellular Function Assays the members of the KappaB-Ras

the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65

and 18 have been described

This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK

Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP)

including hepatocyte nuclear factor 1 alpha

Tuberin Polyclonal Antibody, 50ul[BT-AP09285] Cellular Function Assays the members of the KappaB-RasMutations in TSC2 (tuberous sclerosis 2) lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.