ALK-1 Polyclonal Antibody, 50ul[BT-AP00374] Pipette Filler The protein encoded by PLCG1

The protein encoded by PLCG1 (phospholipase C gamma 1) catalyzes the formation of inositol 1

The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation

MIM 613213) (Zhu et al

some of which are disease-associated mutations

These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II

ALK-1 Polyclonal Antibody, 50ul[BT-AP00374] Pipette Filler The protein encoded by PLCG1ACVRL1 encodes a type I cell surface receptor for the TGF beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine threonine kinase subdomains, a glycine and serine rich region (called the GS domain) preceding the kinase domain, and a short C terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor like kinase proteins