PLEK2 Rabbit Polyclonal Antibody, 100ul Roller Bottles Mutations in PRKAR1A cause Carney

Mutations in PRKAR1A cause Carney complex (CNC)

including gene expression

Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene

with the exception of Txk and Dsrc28C

It may also have a chaperone function in the assembly of inner membrane protein complexes| and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome

PLEK2 Rabbit Polyclonal Antibody, 100ul Roller Bottles Mutations in PRKAR1A cause CarneyThe protein encoded by this gene associates with membrane bound phosphatidylinositols generated by phosphatidylinositol 3 kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1 q subcomponent B chain (C1QB) this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.