HP-1 Gamma mouse Monoclonal Antibody(3B9), 50ul Human Genome Knockout Libraries The MAPKKK5 protein phosphorylates and

The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1| MAPKK4) in vitro| and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells

subcellular location:Expressed diffusely throughout the nucleus

Increased expression of this gene is associated with colorectal cancer

Expressed on mature neutrophils but not on immature neutrophils or eosinophils

Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus

HP-1 Gamma mouse Monoclonal Antibody(3B9), 50ul Human Genome Knockout Libraries The MAPKKK5 protein phosphorylates andAt the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds