CCBE1 Polyclonal Antibody, 50ul Biochemical Reagents Alternative splicing of TAF1 results

Alternative splicing of TAF1 results in multiple transcript variants

CDKN2A (cyclin dependent kinase inhibitor 2A) generates several transcript variants which differ in their first exons

act as an integration point for multiple biochemical signals

The activated form of eukaryotic translation initiation factor 2 alpha kinase 2 can phosphorylate translation initiation factor EIF2S1

it lacks the conserved His residue which is normally found 9 residues before the catalytic His

CCBE1 Polyclonal Antibody, 50ul Biochemical Reagents Alternative splicing of TAF1 resultsThis gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia lymphedema syndrome, a generalized lymphatic dysplasia in humans.