Rat Nephrin, NPHN ELISA Kit, 96T Yeast Expression cleaves SPHK2 which is released

cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly

It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines| suggesting that it may play a role in lung tumorigenesis

Component of the cornified envelope of keratinocytes

Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells

and a short C-terminal extracellular region

Rat Nephrin, NPHN ELISA Kit, 96T Yeast Expression cleaves SPHK2 which is releasedSeems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.