p21 (Acetyl Lys154) Rabbit Polyclonal Antibody, 50ul Isothermal Amplification Alternative splicing results in multiple

Alternative splicing results in multiple transcript variants encoding differing isoforms

It binds beta-catenin and negatively regulates Wnt signaling pathway

Among its related pathways are Platinum Pathway

This gene may contribute to the transcriptional control of cell growth and differentiation

The gene is part of a cluster of MMP genes on chromosome 11

p21 (Acetyl Lys154) Rabbit Polyclonal Antibody, 50ul Isothermal Amplification Alternative splicing results in multipleMay be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin dependent kinase activity preventing phosphorylation of critical cyclin dependent kinase substrates and blocking cell cycle progression. induction: By p53 mezerein (antileukemic compound) and interferon beta. PTM: Phosphorylation of Thr 145 by Akt or of Ser 146 by PKC impairs binding to