JAM3 Polyclonal Antibody, 20ul 3D Cell Culture Consumables Interleukin-1 receptor-associated kinase 3 is

Interleukin-1 receptor-associated kinase 3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling

Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546| 20937277)

Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH)

and may play a role in regulating the actin cytoskeleton

A pseudogene exists on chromosome 18

JAM3 Polyclonal Antibody, 20ul 3D Cell Culture Consumables Interleukin-1 receptor-associated kinase 3 isTight junctions represent one mode of cell to cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable