PPR1A Polyclonal Antibody, 50ul Supplements This gene is part of

This gene is part of the family of Rho guanine nucleotide exchange factors

Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin

The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the Catalytic activity is acquired

Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet

It is the rate-limiting enzyme in the synthesis of catecholamines

PPR1A Polyclonal Antibody, 50ul Supplements This gene is part ofInhibitor of protein phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I 1 activity in many tissues. I 1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I 1 is inactivated by calcineurin (or PP2B). Does not inhibit type 2 phosphatases.,PTM: Phosphorylation of Thr 35 is