SAE1 Polyclonal Antibody, 100ul Metabolic enzymes Variations in this gene have

Variations in this gene have been linked to metabolic syndrome

This gene is a putative tumor suppressor

The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways

cofactor:Binds 2 cobalt ions per subunit

and sequence variants of this gene are also associated with atrial fibrillation

SAE1 Polyclonal Antibody, 100ul Metabolic enzymes Variations in this gene havePosttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO activating enzyme for the sumoylation of proteins.