Sp3/4 Polyclonal Antibody, 100ul Enzyme-Linked Immunosorbent Assay (ELISA) The RB tumor suppressor gene

The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes

Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer

and thereby protect cells against oxidative damage

as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias

Sp3/4 Polyclonal Antibody, 100ul Enzyme-Linked Immunosorbent Assay (ELISA) The RB tumor suppressor geneSP3 (Sp3 transcription factor) belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC and GT box regulatory elements in target genes. This protein contains a zinc finger DNA binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes.