Neurofibromin Polyclonal Antibody, 50ul Glassware Sets The inner- and outer-arm dyneins

The inner- and outer-arm dyneins

autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13)

The expression of this gene is up-regulated by interferon gamma in Th1 cells

The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain

It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation

Neurofibromin Polyclonal Antibody, 50ul Glassware Sets The inner- and outer-arm dyneinsNF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA >Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.