Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Additional alternatively spliced transcript variants

Additional alternatively spliced transcript variants of DYRK4 have been described

|Functions in the lectin pathway of complement| which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them

Mutations in TUFM have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy

This protease also functions to process the precursor SUMO proteins into their mature form

In tumor microenvironments

Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Additional alternatively spliced transcript variantsThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.