EGF Receptor(Phospho-Thr669) Rabbit Polyclonal Antibody, 20ul Cell Labeling & Imaging Mutations in this gene are

Mutations in this gene are associated with ataxia telangiectasia| an autosomal recessive disorder

It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes

This gene belongs to the family of reticulon encoding genes

and may be involved in the trafficking of and interaction between endosomal compartments

It is not active until the last four amino acids of the carboxy-terminus have been cleaved off

EGF Receptor(Phospho-Thr669) Rabbit Polyclonal Antibody, 20ul Cell Labeling & Imaging Mutations in this gene areThe protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.