ADNP Polyclonal Antibody, 100ul Vortex Mixer Ubiquitin-like modifier-activating enzyme 1 encoded

Ubiquitin-like modifier-activating enzyme 1 encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation

The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function| although processing of NFKB1/p105 also appears to occur post-translationally

Mutations in this gene have been associated with Charcot-Marie-Tooth disease

The encoded kinase (casein kinase 1 gamma 1) plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin

Nine mammalian isotypes have been identified

ADNP Polyclonal Antibody, 100ul Vortex Mixer Ubiquitin-like modifier-activating enzyme 1 encodedVasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. ADNP encodes activity dependent neuroprotector homeobox that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a